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	<title>medicine Archives - Massachusetts Medical Marijuana Doctors: Inhale MD</title>
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		<title>Cannabis Products with Multiple Ingredients: What You Should Know &#8211; Part 1</title>
		<link>https://inhalemd.com/blog/cannabis-products-with-multiple-ingredients-what-you-should-know-part-1/</link>
		
		<dc:creator><![CDATA[Jordan Tishler]]></dc:creator>
		<pubDate>Tue, 04 Feb 2025 12:00:00 +0000</pubDate>
				<category><![CDATA[Medical Marijuana Benefits and Effects]]></category>
		<category><![CDATA[Cannabis]]></category>
		<category><![CDATA[CBC]]></category>
		<category><![CDATA[CBD]]></category>
		<category><![CDATA[CBG]]></category>
		<category><![CDATA[CBN]]></category>
		<category><![CDATA[marijuana]]></category>
		<category><![CDATA[medicine]]></category>
		<category><![CDATA[THC]]></category>
		<category><![CDATA[thc-a]]></category>
		<category><![CDATA[thc-v]]></category>
		<guid isPermaLink="false">https://inhalemd.com/?p=7448</guid>

					<description><![CDATA[<p>As you are likely aware, in the race to differentiate their products from everyone else’s, companies are creating products with a veritable fruit-salad of cannabinoids and other ingredients.&#160; Further, they are marketing these new products for particular use, like sleep, relaxation, or energy.&#160; Overall, these new products are confusing to patients – it’s hard to [&#8230;]</p>
<p>The post <a href="https://inhalemd.com/blog/cannabis-products-with-multiple-ingredients-what-you-should-know-part-1/">Cannabis Products with Multiple Ingredients: What You Should Know &#8211; Part 1</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
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<p>As you are likely aware, in the race to differentiate their products from everyone else’s, companies are creating products with a veritable fruit-salad of cannabinoids and other ingredients.&nbsp; Further, they are marketing these new products for particular use, like sleep, relaxation, or energy.&nbsp;</p>



<p>Overall, these new products are confusing to patients – it’s hard to keep track of all these ingredients, and to know which ingredients are actually safe or helpful.&nbsp; It’s hard to know if you can trust these companies’ statements (or implications) that their products are good for a particular problem or diagnosis.</p>



<p>Let’s review these ingredients and talk about what we really know about their safety and effects.</p>



<h2 class="wp-block-heading">A Review of Cannabinoids</h2>



<p>In this section we’ll look at the cannabinoids that are commonly being sold.&nbsp; There are, of course, many others, but we’ll focus on those that are being pushed at the moment.&nbsp;</p>



<p>Let’s remember that the major medicinal chemicals in cannabis are called cannabinoids.&nbsp; There are other chemicals in cannabis including terpenoids and flavonoids that are not currently being specifically added to products and for which there are even fewer data.</p>



<h2 class="wp-block-heading">THC (Tetrahydrocannabinol)</h2>



<p>THC is the main medicine.&nbsp; It has been researched for over 70 years and we have good safety and efficacy data in humans.&nbsp; While the lay-press is often quick to point out that it’s “the part that gets you high” – which is true – it overlooks the proven medical value for pain, sleep, nausea, headache, anxiety, and other symptoms.&nbsp;</p>



<p>THC also can be misused and can cause dependence.&nbsp; Intoxication needs to be managed as a side effect as with all medications.&nbsp; THC is the primary ingredient to look for and must be used with caution under the guidance of a knowledgeable clinician.&nbsp;</p>



<h2 class="wp-block-heading">CBD (Cannabidiol)</h2>



<p>CBD is vastly popular at the moment.&nbsp; However, this is mostly as a result of legal policy, not medical efficacy.&nbsp; CBD has been demonstrated in the test-tube or in mice to have a range of exciting potential benefits, including being anti-inflammatory, anti-seizure, anti-pain, and perhaps pro-sleep.&nbsp; CBD has been approved by FDA as a drug called Epidiolex for treatment of seizures in children with rare genetic seizure disorders called Dravet’s, Lennox-Gastaut, and Tuberous Sclerosis syndromes.&nbsp;</p>



<p>However, other than for those children with these rare genetic disorders, there has been no successful translational research done to prove benefit from CBD to adult humans with other conditions.&nbsp; In other words, none of the benefits touted for adults from CBD have been proven in human beings. &nbsp;Very importantly, CBD, more than other cannabinoids, has been shown to interact with a wide range of conventional medications.&nbsp; This poses very real danger.&nbsp; If you are taking any number of heart medications, blood thinners, anti-rejection drugs, or even over-the-counter Claritin, CBD can mess with those medications, possibly even fatally.&nbsp;</p>



<p>Since none of the supposed benefits have been proven in humans but the risks are real and potentially severe, I advise avoiding CBD containing products unless/until new data comes to light.&nbsp;</p>



<h2 class="wp-block-heading">CBN (Cannabinol)</h2>



<p>CBN has long been touted as good for sleep.&nbsp; It’s not clear where this idea comes from, but until recently there were no human studies to confirm or deny.&nbsp; Recently there has been one such study.&nbsp; It showed no benefit for sleep for CBD, but that CBN was helpful for sleep.&nbsp; Unfortunately, this study (for legal reasons) did not include a THC arm, so we don’t know if CBN is better for sleep than plain old THC.&nbsp; It’s possible that 5mg THC plus 2mg CBN is better for sleep than 7mg of THC, or it might be the same.&nbsp; CBN is a relatively benign medicine, so for patients needing sleep it is not unreasonable to see if added CBN helps.</p>



<h2 class="wp-block-heading">CBG (Cannabigerol)</h2>



<p>CBG is another cannabinoid for which we have very little human data.&nbsp; CBG has been touted as anti-inflammatory and possibly neuro-protective (slows down neurodegenerative diseases like Parkinson’s and others) but we have no human data to support those ideas.&nbsp; There has been one study in humans that has shown CBG useful for patients with anxiety.</p>



<p>CBG is non-intoxicating and largely benign but we have so little data to support use that at this time I would not recommend seeking it as an ingredient.</p>



<h2 class="wp-block-heading">CBC (Cannabichromene)</h2>



<p>CBC is yet another cannabinoid that is being thrown into cannabis products.&nbsp; We have no human data on whether it is safe or useful – I would avoid.&nbsp;</p>



<h2 class="wp-block-heading">THC-V (Tetrahydrocannabivarin)</h2>



<p>THC-V is a distant cousin of THC.&nbsp; It, too, can be intoxicating though there is debate on how much and how long it lasts compared to THC.&nbsp; There is also a claim that it suppresses appetite and is often called “diet weed”.&nbsp; Sadly, this has actually been shown in humans not to be the case.&nbsp; However, THC-V has some early human evidence that it improves glycemic control and lipid profiles – so with more data there may, in fact, be use for THC-V.&nbsp; Stay tuned.</p>



<h2 class="wp-block-heading">THC-A (Tetrahydrocannabinolic Acid)</h2>



<p>THC-A is the precursor of THC.&nbsp; The cannabis plant actually makes THC-A, not THC, and we create the THC by burning or otherwise heating the cannabis material.&nbsp; THC-A is non-intoxicating, abundant, and has been shown in human tissue to be a strong anti-inflammatory.&nbsp; There are data showing benefit in humans for auto-immune diseases like Crohn’s, Ulcerative Colitis, and Rheumatoid Arthritis.&nbsp; I have used THC-A successfully to help patients with these diseases.&nbsp; Unfortunately, in the recreationally dominated market, it is rare to find THC-A products available.&nbsp;</p>



<h2 class="wp-block-heading">Next Time</h2>



<p>Now that we’ve covered some of the different cannabinoids found in the cannabis plant and their safety and effects, <a href="https://inhalemd.com/blog/cannabis-products-with-multiple-ingredients-what-you-should-know-part-2/">next time </a>we’ll continue to talk about safety when it comes to additional additives, hemp, and more.</p>



<h2 class="wp-block-heading">Consult with a Qualified Massachusetts Medical Marijuana Expert Today</h2>



<p>Those considering using THC, CBD, or any type of medicine found in cannabis to help manage their condition should consider speaking to a trained medical expert who is knowledgeable about using cannabis therapeutically.&nbsp;</p>



<p><a href="https://inhalemd.com/about-us/" target="_blank" rel="noreferrer noopener">Massachusetts medical marijuana doctor Jordan Tishler</a>, M.D. sits on the faculty of Harvard Medical School and has years of experience helping patients treat pain and other ailments using cannabis. He and the team at&nbsp;<em>inhaleMD&nbsp;</em>stand ready to assist patients in determining whether medical marijuana is right for them.</p>



<p>For more information, or to set up a virtual consultation with the team at&nbsp;<em>inhaleMD</em>, call us at (617) 477-8886 today.</p>
<p>The post <a href="https://inhalemd.com/blog/cannabis-products-with-multiple-ingredients-what-you-should-know-part-1/">Cannabis Products with Multiple Ingredients: What You Should Know &#8211; Part 1</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
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		<title>Smoking: Bong vs. Joint</title>
		<link>https://inhalemd.com/blog/bong-vs-joint/</link>
		
		<dc:creator><![CDATA[Jordan Tishler]]></dc:creator>
		<pubDate>Tue, 07 Jan 2025 12:00:00 +0000</pubDate>
				<category><![CDATA[How to Use Marijuana]]></category>
		<category><![CDATA[Cannabis]]></category>
		<category><![CDATA[care]]></category>
		<category><![CDATA[doctor]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[joint]]></category>
		<category><![CDATA[marijuana]]></category>
		<category><![CDATA[medicine]]></category>
		<category><![CDATA[smoking]]></category>
		<category><![CDATA[vaporize]]></category>
		<category><![CDATA[vaporizing]]></category>
		<guid isPermaLink="false">https://inhalemd.com/?p=7403</guid>

					<description><![CDATA[<p>As you know, if you’ve been following along with me over the years, I generally do not recommend smoking cannabis.&#160; I tend to recommend vaporizing whole flower as the safest approach to inhalation that actually allows us to estimate dose fairly accurately.&#160; Recently, however, I was confronted with the question of whether using a bong [&#8230;]</p>
<p>The post <a href="https://inhalemd.com/blog/bong-vs-joint/">Smoking: Bong vs. Joint</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
]]></description>
										<content:encoded><![CDATA[
<p>As you know, if you’ve been following along with me over the years, I generally do not recommend smoking cannabis.&nbsp; I tend to recommend <a href="https://inhalemd.com/blog/what-temperature-should-i-be-vaporizing-at/">vaporizing </a>whole flower as the safest approach to inhalation that actually allows us to estimate dose fairly accurately.&nbsp; Recently, however, I was confronted with the question of whether using a bong vs. joint was better.&nbsp; Let’s explore.</p>



<h2 class="wp-block-heading">Risk of Smoking</h2>



<p>Why do I generally recommend against smoking?&nbsp; Smoking exposes us to a wide array of nasty chemicals from the combustion of the plant material and terpenes.&nbsp; Most of these nasty chemicals are known to promote cancer, heart disease, high blood pressure, and lung disease.&nbsp; The overlap in nasty chemicals between cannabis smoke and tobacco smoke is impressive.&nbsp; Hence I recommend avoiding these when we can.</p>



<p>Interestingly, and in full transparency, cannabis smokers don’t seem to get the same emphysema and lung cancers that we see with tobacco smokers.&nbsp; You may have heard of the study that Dr. Donald Tashkin at UCLA started back in 1980s following recreational cannabis smokers that has amply demonstrated these differences.&nbsp; Nonetheless, we clearly don’t understand why these differences should exist given the similarities in the nasty chemicals in both that we’ve already discussed.&nbsp; Perhaps there are some chemicals in cannabis smoke that mitigate the negative effect found in tobacco smoke, but that seems less plausible.&nbsp; Perhaps we just aren’t looking at the right harms and cannabis smokers do get something bad from these nasties.&nbsp; We just don’t know.&nbsp; Again, this is why I recommend avoiding the avoidable exposure.&nbsp;</p>



<h2 class="wp-block-heading">Risk of Dosing</h2>



<p><a href="https://inhalemd.com/blog/top-reasons-for-inhalation/">Inhalation </a>as a method of cannabis use poses some risk itself due to dosing effects.&nbsp; Whether we’re talking about smoking or vaporizing flower, there is a tendency for users to not focus on their dose.&nbsp; When I teach patients to use cannabis via a flower vaporizer, I teach them to take a “puff” in a specific manner that leads to a consistent dose per puff.&nbsp; Nonetheless, even if the dose per puff is known, it requires the user to pay attention to how many puffs they take.&nbsp; This is easily done for many, but for some it is just too easy to not pay attention and puff away.&nbsp; Very quickly this can lead to taking much more cannabis than intended.&nbsp; This becomes problematic as higher doses push up tolerance, which then lead to using a still higher dose, and this can escalate the dose ever higher.&nbsp; At some point these ever higher doses lead to down-regulation of endocannabinoid receptors, malfunction of the Endocannabinoid System, dependence, and even addiction.&nbsp;</p>



<p>The best way to avoid this vicious cycle is, of course, to use the flower vaporizer with care and to respect your dose.&nbsp; Counting puffs is not that difficult.&nbsp;</p>



<h2 class="wp-block-heading">Bong vs. Joint for Dosing</h2>



<p>If someone is hell-bent on smoking (and this article really shouldn’t be used to justify that), the bong does present a better option than the joint.&nbsp;</p>



<p>When you smoke a joint, you watch much of the smoke spiral off into the universe, lost from being available to help you.&nbsp; Estimates of how much that may be vary and are not well documented.&nbsp; However, it appears to be somewhere between 50-70% is lost to the “side stream” meaning into the ether.&nbsp; This makes understanding how much you’re actually taking in very difficult.&nbsp; You can do the math, but it’s woefully imprecise.&nbsp;</p>



<p>Furthermore, most patients and cannabis users are quite cost conscious, so losing &gt;50% of your medicine seems like a dramatic, avoidable waste of money.&nbsp;</p>



<p>Bongs are different.&nbsp; Not only do they trap the smoke in a container so that it is not lost when you stop inhaling, and that smoke remains available in that container when you resume inhaling, but they generally don’t stay lit when you cease the inhalation.&nbsp; This means that much less is lost to the side stream.&nbsp; It appears that the loss is about 10% &#8211; meaning that you get to use about 90%.</p>



<p>Since bongs are so much more efficient, we can do <a href="https://inhalemd.com/blog/calculate-your-dose/">dosing </a>much more precisely.  To do this we start with the dose we need, back calculate how much cannabis needs to go into the bong, and at 90% retention, we have a good idea what you’re getting.  Let me give you an example:</p>



<p>If your dose is 10mg THC, and you buy a 20% THC strain, then 50mg of cannabis equals 10mg THC (here’s the math – 10/0.2 = 50).&nbsp; You can do the same math with odd percentages too.&nbsp; If the strain has 17.3% THC, then the 10mg THC dose is 10/0.173 = 57.8mg cannabis.</p>



<p>So if you put 57.8mg of 17.3% THC cannabis into your bong and smoke it, you’ll be getting about 9mg THC which, as they say, is close enough to 10mg for rock and roll.&nbsp;</p>



<h2 class="wp-block-heading">Vaporizing is Best</h2>



<p>In the end, there’s really no good reason to smoke cannabis.&nbsp; It’s really an unnecessary risk when you consider that you’re using cannabis as a medicine.&nbsp; Dosing is really important too, for all the reasons I’ve given above.&nbsp; So if you must smoke, then a bong at least allows control of dose.&nbsp; It’s up to you to follow the math (I’ll be happy to help) and to stick to the dosing and timing we discuss in your care plan.&nbsp;</p>



<h2 class="wp-block-heading">Consult with a Qualified Massachusetts Medical Marijuana Expert Today</h2>



<p>Those considering using THC, CBD, or any type of medicine found in cannabis to help manage their condition should consider speaking to a trained medical expert who is knowledgeable about using cannabis therapeutically.&nbsp;</p>



<p><a href="https://inhalemd.com/about-us/" target="_blank" rel="noreferrer noopener">Massachusetts medical marijuana doctor Jordan Tishler</a>, M.D. sits on the faculty of Harvard Medical School and has years of experience helping patients treat pain and other ailments using cannabis. He and the team at&nbsp;<em>inhaleMD&nbsp;</em>stand ready to assist patients in determining whether medical marijuana is right for them.</p>



<p>For more information, or to set up a virtual consultation with the team at&nbsp;<em>inhaleMD</em>, call us at (617) 477-8886 today.</p>
<p>The post <a href="https://inhalemd.com/blog/bong-vs-joint/">Smoking: Bong vs. Joint</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
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		<title>What Is the Cannabis Entourage Effect and What Does It Mean to Me?</title>
		<link>https://inhalemd.com/blog/cannabis-entourage-effect/</link>
		
		<dc:creator><![CDATA[Jordan Tishler]]></dc:creator>
		<pubDate>Tue, 15 Oct 2024 11:00:00 +0000</pubDate>
				<category><![CDATA[How to Use Marijuana]]></category>
		<category><![CDATA[Medical Marijuana Benefits and Effects]]></category>
		<category><![CDATA[Cannabis]]></category>
		<category><![CDATA[care]]></category>
		<category><![CDATA[CBD]]></category>
		<category><![CDATA[doctor]]></category>
		<category><![CDATA[entourage effect]]></category>
		<category><![CDATA[marijuana]]></category>
		<category><![CDATA[medicine]]></category>
		<category><![CDATA[THC]]></category>
		<guid isPermaLink="false">https://inhalemd.com/?p=5375</guid>

					<description><![CDATA[<p>The theory behind the entourage effect says that combining the compounds in the cannabis plant creates an outcome that is different than the effect of a single compound consumed by itself.  The components in cannabis plantsare greater than the sum of their parts. The compounds act synergistically to draw additional effects out of each component present in the plant.</p>
<p>The post <a href="https://inhalemd.com/blog/cannabis-entourage-effect/">What Is the Cannabis Entourage Effect and What Does It Mean to Me?</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p>Cannabis is becoming widely recognized as a safe and viable treatment for a range of illnesses, including chronic pain, anxiety, nausea, insomnia, and others.  Generally, research over the past 70 years has focused on the benefits of THC.  More recently CBD and to a lesser degree other cannabinoids like CBN, CBG, CBC, THC-A, and THC-V have begun to appear on the market.  Research on these cannabinoids is in its infancy and none of these have adequate data behind them to be useable in adult human beings.</p>
<p>Still, we have ample experience that whole cannabis behaves differently from synthetic THC available as an FDA-approved pharmaceutical called Dronabinol.  This could be simply because the synthetic THC is structurally different from plant-derived THC, but has also lent credence to the idea of the Entourage Effect (more properly called the Entourage Hypothesis).</p>
<p>According to the concept of the entourage effect, each of the compounds in the cannabis plant works together with the other compounds to create an effect in the user that is greater than each of the compounds alone. Continue reading from our <a href="https://inhalemd.com/">Massachusetts medical marijuana doctor</a> to learn more about how the entourage effect might work and what it means for <span>medical marijuana patients</span>.</p>
<h2><span>Understanding Cannabis&#8217;s Entourage Effect </span></h2>
<p>The theory behind the entourage effect says that combining the compounds in the cannabis plant creates an outcome that is different than the effect of a single compound consumed by itself.  Essentially, the entourage effect claims that the components in both types of cannabis plants, marijuana and hemp, are greater than the sum of their parts. The compounds act synergistically to draw additional effects out of each component present in the plant.</p>
<p>The entourage effect has led many experts in the cannabis industry to advocate for a holistic, whole-plant approach regarding cannabis products. Instead of isolating one ingredient or compound in the cannabis plant for the patient to use, proponents of the entourage effect recommend using several components that can interact with each other in the patient’s body to create the effect that is most beneficial to their <span>health and well-being</span>.</p>
<p>The cannabis plant is comprised of more than 480 natural components, only about 140 of which are cannabinoids. Cannabinoids are the compounds unique to the cannabis plant and include the popular compounds tetrahydrocannabinol (THC) and cannabidiol (CBD), as well as cannabigerol (CBG), cannabichromene (CBC), and cannabielsoin (CBE).</p>
<p>There is a wide variety of other compounds present in the cannabis plant that could play a role in the effect that marijuana has on a user. Terpenoids, for example, are the compound that give each strain of its marijuana its individual flavor and smell. There are about 120 different terpenes present in the cannabis plants, each of which might interact with the other compounds present in the plant. Other compounds include lactones, steroids, flavonoids, and other elements.</p>
<h2><span>What the Cannabis Entourage Effect Can Mean for You</span></h2>
<p>A recent study that reviewed the evidence for the entourage effect concluded that the concept remains reasonable and that there is some evidence to support this idea, but that it was in no way proven.  So, more research to come.</p>
<p>In the meantime, as we focus on treatments with the most <a href="https://inhalemd.com/massachusetts-medical-cannabis-guide/what-are-the-health-benefits-of-medical-marijuana/">health benefits of cannabis</a> possible for <span>you and your health, </span> it’s important to pay remember to aim for whole-plant products.  These products are often called &#8220;full spectrum&#8221;, which means the product contains most of the compounds found in the cannabis plant, including an array of cannabinoids, terpenes, vitamins, fatty acids, proteins, and more. These products are most likely to help users deal with many common ailments, including inflammation, <a href="https://inhalemd.com/boston-medical-marijuana-doctor-for-chronic-conditions/">chronic pain</a>, <span><a href="https://inhalemd.com/medical-marijuana-anxiety-boston-massachusetts/">anxiety</a></span>, <a href="https://inhalemd.com/medical-marijuana-for-depression-treatment-in-boston/">depression</a>, epilepsy, and multiple sclerosis.</p>
<h2><span>Consult a Massachusetts Medical Marijuana Doctor</span></h2>
<p>The experts at InhaleMD would like to help patients understand the entourage effect and how it can affect their use of medical marijuana products. If you would like to learn more about how you can utilize the entourage effect to make the most of your own medical marijuana use, get in touch with the <span><a href="https://inhalemd.com/massachusetts-medical-cannabis-guide/boston-medical-marijuana-doctor/">Massachusetts medical marijuana doctors</a></span> at InhaleMD as soon as possible. Call (617) 477-8886 today.</p>
<p>The post <a href="https://inhalemd.com/blog/cannabis-entourage-effect/">What Is the Cannabis Entourage Effect and What Does It Mean to Me?</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
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		<title>Effects and Risks of Using Medical Marijuana for Anxiety</title>
		<link>https://inhalemd.com/blog/medical-marijuana-for-anxiety/</link>
		
		<dc:creator><![CDATA[Jordan Tishler]]></dc:creator>
		<pubDate>Tue, 01 Oct 2024 11:00:00 +0000</pubDate>
				<category><![CDATA[Medical Marijuana Benefits and Effects]]></category>
		<category><![CDATA[anxiety]]></category>
		<category><![CDATA[Cannabis]]></category>
		<category><![CDATA[card]]></category>
		<category><![CDATA[care]]></category>
		<category><![CDATA[CBD]]></category>
		<category><![CDATA[diy]]></category>
		<category><![CDATA[doctor]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[marijuana]]></category>
		<category><![CDATA[medicine]]></category>
		<category><![CDATA[THC]]></category>
		<guid isPermaLink="false">https://inhalemd.com/?p=7111</guid>

					<description><![CDATA[<p>Anxiety is one of the reasons that people seek treatment using medical marijuana. Getting benefit for anxiety comes down to dose and timing.</p>
<p>The post <a href="https://inhalemd.com/blog/medical-marijuana-for-anxiety/">Effects and Risks of Using Medical Marijuana for Anxiety</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
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<p>Anxiety is one of the most common reasons that people seek treatment using medical marijuana. However it is also the most common problem that can be made worse by cannabis. The critical dividing line between getting <a href="https://inhalemd.com/blog/5-best-strains-of-marijuana-for-anxiety/">benefit for anxiety from medical cannabis</a> and getting worse when using medical cannabis comes down to both dose and the timing of that dose. </p>



<p>You can imagine a very unfortunate scenario in which somebody starts using cannabis to treat their anxiety, but gets bad advice on how to do so which leads to their using cannabis excessively which leads to more anxiety. Needless to say, then they use more cannabis which leads to more anxiety and now we have a vicious cycle. This is exactly what we need to avoid.</p>



<p>The key, then, is to avoid the pitfalls that are so commonly seen and repeated in the cannabis using community. This means careful attention, again, to <a href="https://inhalemd.com/blog/calculate-your-dose/">dose</a> and timing.</p>



<h2 class="wp-block-heading">The Effect of Cannabis on Anxiety</h2>



<p>Cannabis works by interacting with our internal signalizing system called the <a href="https://www.cannaspecialists.org/the_endocannabinoid_system_slowly_unraveling_the_unknown">Endocannabinoid System</a>.&nbsp; This system is responsible for a wide range of processes including mood, sleep, pain, memory and others.&nbsp; It interacts with other important systems like the serotonin, dopamine, glutamate, and opioid signaling pathways.&nbsp; </p>



<p>Using cannabinoids judiciously can strengthen the functioning of these systems, but improper use can undermine the balance between all these important functions and create a downward spiral.&nbsp;</p>



<h2 class="wp-block-heading">Long-term Studies</h2>



<p>Most of the science about cannabis for anxiety is deeply flawed.&nbsp; This is largely due to the legalities impeding proper study which has led to studies that do not appropriately account for dose and timing.&nbsp; In sorting through the vast number of these studies, it’s critical to evaluate the methodology to see if there is any attention to these important factors.&nbsp;</p>



<p>Naturalistic studies have demonstrated that excessive use of cannabis can lead to decreases in school/work performance.&nbsp; Day time use of cannabis has been implicated in this dysfunction as well.&nbsp; Similar research has demonstrated that excessive use can worsen both anxiety and depression, leading to that vicious cycle mentioned above.&nbsp;&nbsp;</p>



<p>More recent studies have shown two interesting phenomena:&nbsp; lower doses are more effective and do not seem to provoke worsening anxiety, and that dosing around bedtime avoids day time use and provides benefit throughout the next day.&nbsp; The meaning of these observations is that low-doses can be helpful, and less likely harmful, and that the effect of cannabis on anxiety isn’t directly tied to being intoxicated (being stoned).&nbsp; In fact, the intoxication can be fully viewed as a side-effect to be best slept off overnight.&nbsp;</p>



<h2 class="wp-block-heading">Comparison to Conventional Medications</h2>



<p>It’s also clear that the benefit of cannabis for anxiety and depression is fairly weak.&nbsp; It is perhaps similar to a starting dose of an SSRI.&nbsp; Some people do get the benefit they need at those starting doses of conventional medication, and so low-dose cannabis may be an alternative for them.&nbsp; However, most people will need more of that conventional medication and for them cannabis is not a good substitute.&nbsp;&nbsp;</p>



<p>Importantly, this is not an either/or situation.&nbsp; Cannabis can be used safely and effectively as an adjunct to conventional medications providing both some additional effectiveness for the treatment of the anxiety, and also helping to undo some of the negatives that come along with conventional anxiety medications (like ennui, and various sexual side effects).</p>



<h2 class="wp-block-heading">Seeking Help</h2>



<p>As we’ve discussed, the dose and timing of that dose is critical to <strong>safe and effective treatment of anxiety</strong>.  Furthermore, we’ve noted that for anxiety and depression, more than for other conditions, the approaches to treatment being discussed among lay-people are incorrect and likely to create that vicious cycle of ever-increasing anxiety.  To avoid those pitfalls, dose and timing are the crucial elements, as is getting proper medical guidance and follow-up.  </p>



<p>Your healthcare shouldn’t be a DIY project like painting the spare bedroom or washing your car.&nbsp; The consequences of getting it wrong are far worse and long-term.&nbsp; Please seek real medical care.&nbsp;</p>



<h2 class="wp-block-heading">Consult with a Qualified Massachusetts Medical Marijuana Expert Today</h2>



<p>Those considering using THC, CBD, or any type of medicine found in cannabis to help manage their condition should consider speaking to a trained medical expert who is knowledgeable about using cannabis therapeutically.&nbsp;</p>



<p><a href="https://inhalemd.com/about-us/" target="_blank" rel="noreferrer noopener">Massachusetts medical marijuana doctor Jordan Tishler</a>, M.D. sits on the faculty of Harvard Medical School and has years of experience helping patients treat pain and other ailments using cannabis. He and the team at&nbsp;<em>InhaleMD&nbsp;</em>stand ready to assist patients in determining whether medical marijuana is right for them.</p>



<p>For more information, or to&nbsp;<a href="https://inhalemd.com/cannabiscare">set up a virtual consultation</a>&nbsp;with the team at InhaleMD, call us at (617) 477-8886 today.</p>



<p></p>
<p>The post <a href="https://inhalemd.com/blog/medical-marijuana-for-anxiety/">Effects and Risks of Using Medical Marijuana for Anxiety</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
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		<title>Why Gummies Aren&#8217;t the Answer for Everything</title>
		<link>https://inhalemd.com/blog/why-gummies-arent-the-answer-for-everything/</link>
		
		<dc:creator><![CDATA[Jordan Tishler]]></dc:creator>
		<pubDate>Tue, 17 Sep 2024 11:00:00 +0000</pubDate>
				<category><![CDATA[How to Use Marijuana]]></category>
		<category><![CDATA[Cannabis]]></category>
		<category><![CDATA[CBD]]></category>
		<category><![CDATA[doctor]]></category>
		<category><![CDATA[edible]]></category>
		<category><![CDATA[gummy]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[marijuana]]></category>
		<category><![CDATA[medicine]]></category>
		<category><![CDATA[THC]]></category>
		<guid isPermaLink="false">https://inhalemd.com/?p=7094</guid>

					<description><![CDATA[<p>Gummies, or orally ingested cannabis medicines, are usually the right answer (despite the name of my practice).  Inhalation definitely has its place, but it’s less common than one might think.  Since dosing and adherence to the plan is critical to getting best and safest results, inhalation poses some additional risk.  Regimens should be tailored to the medical needs of the patient, which includes assessment and discussion of risk.  </p>
<p>The post <a href="https://inhalemd.com/blog/why-gummies-arent-the-answer-for-everything/">Why Gummies Aren&#8217;t the Answer for Everything</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
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<p>There is a certain irony for me in this topic.&nbsp; I have a history of choosing poor names for my companies, and while in the early 2010s I thought that <em>inhaleMD </em>was a good way of avoiding pigeon-holing myself as a cannabis doctor (I actually thought it would sound like a pulmonary clinic) I guess I wasn’t actually fooling anybody.&nbsp; However, it did reflect my view at the time that most cannabis treatment should be done <a href="https://www.cannaspecialists.org/dont_smoke_your_medicine" target="_blank" rel="noreferrer noopener">via inhalation</a>.&nbsp; I’ve come a long way, baby, since then and so have the scientific data.&nbsp;&nbsp;</p>



<p>When I first started in this field, I typically recommended inhalation about 75% of the time and oral ingestion (gummies) about 25% of the time.&nbsp; My thinking, following the data and over 12 years of clinical experience, as completely reversed those numbers.&nbsp; Now it’s almost always oral ingestion and less commonly inhalation.&nbsp;&nbsp;</p>



<p>However, inhalation most definitely has its place and we’ll discuss its role and the decision-making process here.&nbsp;&nbsp;</p>



<h2 class="wp-block-heading">Decision Making</h2>



<p>Contrary to the advice you’re likely to be given at the store or by a friend, the way you take cannabis should be chosen, not by personal preference, but by what is going to work best for the illness we need to treat.&nbsp;&nbsp;</p>



<p>Like most medications, cannabis behaves differently depending on how you take it.&nbsp; In the hospital or emergency room we often give medications by IV because they work faster that way.&nbsp; However, we often give the same medication by mouth when the patient goes home since rapidity is no longer paramount, and in fact, longer duration of action becomes more important to the treatment. We need to use the method that is most likely to lead to the benefit we seek.&nbsp;&nbsp;</p>



<p>Additionally, some routes of administration pose greater risk to the patient and that risk factors into the decision-making.&nbsp;</p>



<h2 class="wp-block-heading">Oral Ingestion (Taking Gummies by Mouth)</h2>



<p>Taking a gummy is familiar to almost everybody – it’s pretty similar to taking a pill.&nbsp; In fact, some gummies are small enough you could swallow them whole.&nbsp; When you take cannabis by mouth, like any other pill, it takes a while to kick in.&nbsp; This is usually about an hour, which again, is like most other medications.&nbsp; Cannabis can be a bit more unpredictable due to generally poor absorption, but is generally useable.</p>



<p>A nice benefit of oral ingestion is that, once absorbed from the gut, it visits the liver first (this is called <a href="https://www.ncbi.nlm.nih.gov/books/NBK551679/" target="_blank" rel="noreferrer noopener">First Pass Metabolism</a>) where the active ingredient that you took (delta-9 THC) is converted into another chemical called 11-hydroxy-THC.&nbsp; 11-hydroxy-THC works longer and so we get better coverage for the symptoms we’re addressing.&nbsp;&nbsp;</p>



<p>I think of orally ingested cannabis (aka gummies) as the long-acting form of cannabis.  It’s particularly good for <strong>chronic problems like pain, mood, insomnia, and appetite stimulation.</strong></p>



<p>Another important benefit of oral ingestion is safety.&nbsp; Dosing cannabis properly, just like any other medication, is key to getting the benefit but also to remaining safe.&nbsp; When using gummies that are, say, 5 milligrams each the dosing is pretty simple.&nbsp; If you’re supposed to take 10mg, then you need to take 2 gummies.&nbsp; It’s pretty rare for someone to accidentally or mindlessly take more than a set number of gummies.&nbsp; This helps prevent overdoses and, more importantly, unintentional dose escalation over time.</p>



<h2 class="wp-block-heading">When Would You Want to Use Inhalation?</h2>



<p>Inhalation has its uses!&nbsp; When necessary, there’s no other way really.&nbsp; Let’s remember that when I talk about inhalation I mean vaporized whole flower, not smoking nor vaping which unnecessarily expose you to nasty toxins and heavy metals.&nbsp;</p>



<p>The main use-case for inhalation is acute or episodic problems where the rapidity of onset of the medicine is of paramount importance.&nbsp; Thankfully, this isn’t that common.&nbsp; A good example is a Migraine headache or acute nausea and vomiting.&nbsp; In those cases, getting effective medication working as fast as possible is best.&nbsp; In neither case do you want to take a gummy and wait an hour or so.&nbsp; Inhalation starts to work in about 10 minutes.&nbsp;&nbsp;</p>



<p>On the other hand, inhaled cannabis works for a relatively short period of time, about 3-4 hours.&nbsp; Again this is good for a headache since after the headache abates, we’d like the medicine to wear off too.&nbsp; However, this makes it lousy for those chronic problems I listed in the oral ingestion section above.&nbsp; In fact, for example, using a short-acting medication for chronic pain can actually make the pain worse.&nbsp; Our brains, wily critters that they are, will often learn when the medication is going to wear off and exacerbates the pain when it comes back.&nbsp; Hence, long-acting medications are better.&nbsp;&nbsp;</p>



<p>There are other downsides to inhalation as well.&nbsp; Clearly there is some start-up cost to getting a good vaporizer machine, and there is a bit more process to filling, using, and maintaining the machine.</p>



<p>More important, however, is the risk associated with inhalation compared to oral ingestion.&nbsp; Dosing by inhalation can be done quite precisely and I teach my patients how to do so.&nbsp; But, it requires paying attention and the discipline to adhere to the regimen exactly.&nbsp; While taking, say, two gummies is pretty obvious, taking 2 puffs on the vaporizer feels less obvious.&nbsp; This leads to the very real possibility that 2 puffs becomes 3 puffs and then over time becomes 4 puffs and so on.&nbsp; It’s quite common for someone who should be on 2 puffs to suddenly find themselves at 5-6 puffs (which is clearly 3 times the intended dose).&nbsp; Risk of accelerating tolerance, dependence, and even addiction rise once over 4 puffs.&nbsp; With inhalation it’s just easier to exceed the regimen and to exceed the safe range.&nbsp;</p>



<h2 class="wp-block-heading">The Bottom Line</h2>



<p>Gummies, or orally ingested cannabis medicines, are usually the right answer (despite the name of my practice).&nbsp; Inhalation definitely has its place, but it’s less common than one might think.&nbsp; Since dosing and adherence to the plan is critical to getting best and safest results, inhalation poses some additional risk.&nbsp; Regimens should be tailored to the medical needs of the patient, which includes assessment and discussion of risk.&nbsp;&nbsp;</p>



<h2 class="wp-block-heading">Consult with a Qualified Massachusetts Medical Marijuana Expert Today</h2>



<p>Those considering using THC, CBD, or any type of medicine found in cannabis to help manage their condition should consider speaking to a trained medical expert who is knowledgeable about using cannabis therapeutically.&nbsp;</p>



<p><a href="https://inhalemd.com/about-us/" target="_blank" rel="noreferrer noopener">Massachusetts medical marijuana doctor Jordan Tishler</a>, M.D. sits on the faculty of Harvard Medical School and has years of experience helping patients treat pain and other ailments using cannabis. He and the team at <em>InhaleMD </em>stand ready to assist patients in determining whether medical marijuana is right for them.</p>



<p>For more information, or to&nbsp;<a href="https://inhalemd.com/cannabiscare">set up a virtual consultation</a>&nbsp;with the team at InhaleMD, call us at (617) 477-8886 today.</p>
<p>The post <a href="https://inhalemd.com/blog/why-gummies-arent-the-answer-for-everything/">Why Gummies Aren&#8217;t the Answer for Everything</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
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		<title>Conventional Drugs’ Effects on Cannabinoid Medications</title>
		<link>https://inhalemd.com/blog/conventional_drugs_effects_on-cannabinoid_medications/</link>
		
		<dc:creator><![CDATA[Jordan Tishler]]></dc:creator>
		<pubDate>Tue, 03 Sep 2024 11:00:00 +0000</pubDate>
				<category><![CDATA[Medical Marijuana Benefits and Effects]]></category>
		<category><![CDATA[cannabinoid]]></category>
		<category><![CDATA[Cannabis]]></category>
		<category><![CDATA[CBC]]></category>
		<category><![CDATA[CBD]]></category>
		<category><![CDATA[CBG]]></category>
		<category><![CDATA[Claritin]]></category>
		<category><![CDATA[conventional]]></category>
		<category><![CDATA[doctor]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[interaction]]></category>
		<category><![CDATA[interactions]]></category>
		<category><![CDATA[Loratadine]]></category>
		<category><![CDATA[marijuana]]></category>
		<category><![CDATA[medicial]]></category>
		<category><![CDATA[medicine]]></category>
		<category><![CDATA[Pseudoephedrine]]></category>
		<category><![CDATA[Tacrolimus]]></category>
		<category><![CDATA[THC]]></category>
		<category><![CDATA[Warfarin]]></category>
		<guid isPermaLink="false">https://inhalemd.com/?p=7067</guid>

					<description><![CDATA[<p>There has been a lot of research and a growing awareness of the effect cannabinoids, particularly cannabidiol (CBD), can have on conventional medications.  These effects can increase or decrease the effectiveness of the conventional medication, often with potentially catastrophic results.</p>
<p>The post <a href="https://inhalemd.com/blog/conventional_drugs_effects_on-cannabinoid_medications/">Conventional Drugs’ Effects on Cannabinoid Medications</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
]]></description>
										<content:encoded><![CDATA[
<p>I recently had a clinical experience that shed light on another area of cannabinoid medications that is under-investigated and underreported.  This is the <a href="https://www.fda.gov/drugs/resources-drugs/drug-interactions-what-you-should-know" target="_blank" rel="noreferrer noopener">drug-drug interactions</a> that affect the function of cannabinoids.  </p>



<p>There has been a lot of research and a growing awareness of the effect cannabinoids, particularly cannabidiol (CBD), can have on conventional medications.  These effects can increase or decrease the effectiveness of the <a href="https://inhalemd.com/blog/interactions-between-cannabis-and-common-prescription-medications/" target="_blank" rel="noreferrer noopener">conventional medication</a>, often with potentially catastrophic results.  However, there has been little to no focus on which conventional medications can undermine the benefits (and possibly the safety) of cannabinoid medicines upon which patients are more and more frequently relying.</p>



<h2 class="wp-block-heading">Overview of Cannabinoid Effects on Conventional Medications</h2>



<p>Many medications can be affected by cannabinoids.  There is pretty good information at this point about which medications are affected by tetrahydrocannabinol (THC) and CBD.  There is much less known about the interactions between conventional medications and other cannabinoids like <a href="https://youtu.be/W2oQ7uICZQs" target="_blank" rel="noreferrer noopener">CBG, CBC, CBN, and others</a>.  Nonetheless, many professional drug interaction checkers (programs) now list interactions between THC or CBD and conventional medications.  </p>



<p>These interactions, as mentioned, can be quite important.&nbsp; For examples, CBD can interact with Amiodarone (a powerful and dangerous heart medication), Tacrolimus and Everolimus (cousin immune-suppressant medications that prevent organ rejection in transplant patients) and blood-thinners like Warfarin.&nbsp; CBD can even interact with Loratadine (Claritin) which, in elevated doses, can lead to potentially fatal heart problems.&nbsp;&nbsp;</p>



<p>THC by contrast seems less likely to cause these sorts of problems.  There are a number of medications with which THC can theoretically interact, but among them, only <a href="https://inhalemd.com/blog/drug-interactions-between-cannabis-or-cbd-and-conventional-medications/">Tacrolimus</a> seems to be a reality.</p>



<h2 class="wp-block-heading">What About Conventional Medications Affecting Cannabinoids?</h2>



<p>Anecdotally, we have reports that caffeine interacts with THC to increase the psychotropic effects (makes it more intoxicating).&nbsp; Many recreational users do this deliberately.&nbsp; Similarly, alcohol can increase the intoxication of THC.</p>



<p>The decongestant Pseudoephedrine seems to decrease the effectiveness of THC. Oddly, a similar decongestant, Phenylephrine, does not appear to have the same effect.&nbsp;&nbsp;</p>



<p>CBD, as mentioned, has a lot of interactions with conventional medications.  It is also known, at higher doses, to potentially cause liver toxicity.  It is not known whether that liver toxicity can be exacerbated by other medications that interact with CBD, or are hard on the liver themselves, like Itraconazole, several of the HIV medications, alcohol, and others.  While not directly related to drug interactions, it is also not known whether underlying liver disease like hepatitis B/C or Wilson’s Disease could interact negatively with CBD. </p>



<h2 class="wp-block-heading">Where We Stand</h2>



<p>Far too often both scientific and lay articles end with a call for more research.  I find this both irrefutable and frustrating as it often abdicates making sound, necessary decisions based on what we know now.  In this case, however, we know very little and we do need more research to more fully understand the effects and risks posed by conventional drugs’ interaction with cannabinoid medications. </p>



<p>Moreover, we really need a paradigm shift in the thinking about the role of cannabinoids in medicine, to stop seeing them as recreational substances or alternative meds, and start viewing them as necessary treatments that must not be interfered with any more than any other medication.</p>



<h2 class="wp-block-heading">Consult with a Qualified Massachusetts Medical Marijuana Expert Today</h2>



<p>Those considering using THC, CBD, or any type of medicine found in cannabis to help manage their condition should consider speaking to a trained medical expert who is knowledgeable about using cannabis therapeutically.&nbsp;</p>



<p><a href="https://inhalemd.com/about-us/" target="_blank" rel="noreferrer noopener">Massachusetts medical marijuana doctor Jordan Tishler</a>, M.D. sits on the faculty of Harvard Medical School and has years of experience helping patients treat pain and other ailments using cannabis. He and the team at InhaleMD stand ready to assist patients in determining whether medical marijuana is right for them.</p>



<p>For more information, or to&nbsp;<a href="https://inhalemd.com/cannabiscare">set up a virtual consultation</a>&nbsp;with the team at InhaleMD, call us at (617) 477-8886 today.</p>



<p></p>
<p>The post <a href="https://inhalemd.com/blog/conventional_drugs_effects_on-cannabinoid_medications/">Conventional Drugs’ Effects on Cannabinoid Medications</a> appeared first on <a href="https://inhalemd.com">Massachusetts Medical Marijuana Doctors: Inhale MD</a>.</p>
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